研究集体：干细胞多能性与重编程机理研究集体.pdf
研究集体：干细胞多能性与重编程机理研究集体.pdf
2017 Winners of 2017' Outstanding Science and Technology Achievement Prize of the Chinese Academy of Sciences 年中国科学院杰出科技成就奖获奖者 获 奖 集 体 Research Group of Stem Cell Pluripotency and Reprogramming Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences 干细胞多能性与重编程机理研究集体 T he research group launched the research of stem cell pluripotency early in China, pioneered and positively promoted the iPS cell technology, made systemic progress on cell mechanism and transdifferentiation research, discovered the new application and mechanism of Vitamin C in promoting the stem cell induce efficiency, proposed a new perspective of MET initiating cell reprogramming, set up the reprogram combination and nonintegrated transdifferentiation neural stem cell acquire technology with novel independent intellectual-property rights, opened up a new situation in the research field of stem cell, and vastly enhanced the overall innovation capacity of national stem cell research level. Through introducing international talents and cultivating talent youth, the group formed an innovative research group focusing on stem cell research, and made significant contributions for Chinese stem cell and regenerative medicine research on base construction, talent education and international development and cooperation. 推荐单位：中国科学院广州生物医药与健康研究院 研究集体主要科技贡献： 该研究集体在我国较早开展干细胞多能性研究，率先突破 iPS 干细胞技术并积极推广， 在机理和转分化研究中取得了系统突破，发现维生素 C 提高干细胞诱导效率的新用 集体合影 Group photo 建立全新的自主知识产权的重编程因子组 合，发现C-Jun是重编程的障碍 Established the novel independent reprogramming combination with intellectual-property rights, and discovered that C-Jun is an obstacle of reprogramming 我国在干细胞研究领域的整体创新能力。通过国际引智以及人才培养，形成了以干细 Pei Duanqing 国际化发展与合作等做出了重要贡献。 胞研究为核心的创新研究群体，为我国干细胞与再生医学事业在基地建设、人才培养、 本集体的研究“干细胞多能性与重编程机理研究”获 2013年度国家自然科学二等奖 The group research ”Stem Cell Pluripotency And Reprogram Mechanism” has won second class prize of 2013 “National Natural Science Award” remodeling Pan Guangjin Established the technology of transdifferentiation for neural stem cells, and discovered the function of important transcription factor in the maintainance and differentiation of stem cells. （MET）过程 Discovered the MET progress during cell reprogramming 整合转分化获得神经干细胞新技术等，开创了干细胞研究领域新局面，极大地提高了 Outstanding contributors of this research group Discovered the new application and mechanism of Vitamin C in promoting the stem cell reprogramming efficiency, revealed MET as the key process of initiating reprogramming, and established a novel independent reprogramming combination with intellectual-property rights. 发现重编程过程中存在间充质-上皮转换 途和机制、提出 MET 启动重编程的新视角、建立全新自主知识产权重编程组合与非 研究集体突出贡献者 裴端卿 Miguel A. Esteban 中国科学院广州生物医药与健康研究院 主要科技贡献：发现维生素C提高干细胞诱导效率的新用途和 机制、揭示MET是重编程的关键步骤、建立全新自主知识产权 重编程组合。 Discovered Vitamin C efficiently promotes reprogramming, revealed the molecular mechanism of MET initiates reprogramming, and nominated as the outstanding representative of international science communication. 裴端卿 Pei Duanqing 利用病人尿液细胞获得可移植的神经干细胞 潘光锦 Major contributors The generation of transplantable neural stem cells from human urine cells 中国科学院广州生物医药与健康研究院 主要科技贡献：建立转分化获得神经干细胞的技术，揭示重要 转录因子在干细胞维持和分化中的作用。 Chen Jiekai Wang Tao Qin Baoming Zheng Hui Shu Xiaodong Liu Jing Qin Dajiang 发现Vc能极大提高重编程效率，并通过Jhdm1a/1b作用 发现Vc通过去除组蛋白修饰（H3K9） 促进重编程 促进重编程 Discovered that Vc promotes reprogramming efficiency, and facilitates the reprogramming through Jhdm1a/1b D i s c o v e r e d t h a t Vc p r o m o t e s r e p r og r a m m i ng t h r ou g h r e mov i ng histone modification Liao Baojian 潘光锦 Pan Guangjin Miguel A. Esteban 中国科学院广州生物医药与健康研究院 主要科技贡献：发现维生素C高效促进重编程、揭示MET启始 重编程的分子机理、是国际科技合作交流的优秀代表。 Cai Jinglei Zhang Xiaofei Miguel A. Esteban Guo Lin Sun Hao Chen Keshi Huang Wenhao 15 发现细胞在间充质状态与上皮状态之间的转换有利于提 建立尿液细胞非整合人iPS诱导技术体系 高重编程效率 Established the nonintegrated human iPS system from urine cells Discovered that EMT/ MET between cell status promoting the reprogramming 研究集体主要完成者 陈捷凯 廖宝剑 王 涛 蔡景蕾 秦宝明 张小飞 发现了重编程早期自噬和mTORC1的复杂作用并阐明了 郑 辉 郭 琳 舒晓东 孙 昊 刘 晶 陈可实 秦大江 黄文浩 细胞重塑的发生机制 Discovered the autophagy in early reprogram process and the complicated function of mTORC1, illustrated the mechanism of cell remodeling 16